Important pharmacoki netic and pharmacodynamic properties of a. Jun 28, 2008 eplerenone is a new aldosterone receptor antagonist that will be used in the treatment of hypertension. In vitro and in vivo pharmacologic studies have demonstrated that terbutaline exerts a preferential effect on beta 2adrenergic receptors. Compared with other commonly used antihypertensive medications, eplerenone is effective in lowering blood pressure when used alone or as. Highlights of prescribing information zerbaxa 750 mg 250 mg. Serum potassium monitoring should continue once eplerenone has been re started again. Pentam 300 pentamidine isethionate for injection, an antiprotozoal agent, is a sterile, nonpyrogenic, lyophilized product. The usual starting dose is one 25 mg tablet once daily, increasing after about 4 weeks to 50 mg once daily either as one 50 mg tablet or two 25 mg tablets. Highlights of prescribing information these highlights do not include all the information needed to use avastin safely and effectively.
Page 2 of table of this leaflet is a summary and will not tell you everything about inspra. Although spironolactone and eplerenone are comparably effective. Highlights of prescribing information these highlights do not include all the information needed to use promacta platelet count required to initiate antiviral therapy. Extravasation of etopophos may result in swelling, pain, cellulitis, and necrosis including skin necrosis. Inspra medication page for healthcare professionals to search for scientific information on pfizer medications. Norvir ritonavir tablets, for oral use warnings and precautions norvir ritonavir oral solution the following have been observed in patients receiving norvir. Highlights of prescribing information nss are frequent nss. Package insert dryvax smallpox vaccine, dried, calf lymph type wyeth laboratories, inc. Inspra eplerenone this product information is intended only for residents of the united states.
Highlights of prescribing information these highlights do not include all the information needed to use norvir safely and effectively. Eplerenone tablets are indicated for the treatment of hypertension, to lower blood pressure. Eplerenone fda prescribing information, side effects and uses. Inspra is usually administered together with other medication for heart failure e. Terbutaline sulfate injection is a betaadrenergic receptor agonist. However, its label or package insert may prove confusing to many physicians. Less than 5% of an eplerenone dose is recovered as unchanged drug in the urine and. See full prescribing information for complete boxed warning coadministration of norvir with several classes of drugs including sedative hypnotics, antiarrhythmics, or ergot alkaloid preparations may result in potentially serious andor lifethreatening adverse events due to possible effects of norvir on the hepatic metabolism of certain drugs.
In a separate study, exemestane was given to female rats at 4100 mgkgday beginning 14 days prior to mating and through day 15 or 20 of gestation. Serious pneumocystis jiroveci pneumonia pjp occurred in 0. Eplerenone, a selective mineralocorticoid receptor antagonist, is an approved treatment option for the. Infusion to reduce the development of drugresistant bacteria and maintain the effectiveness of. The product label, or package insert, is the manual for the safe and effective use of a drug. Hepatotoxicity see full prescribing information for complete boxed warning.
Antihypertensive effect of the mineralocorticoid receptor antagonist. In placebocontrolled studies, the overall rates of adverse events were 47% with inspra and 45% with placebo. Nov 30, 2018 terbutaline sulfate, usp, the active ingredient of terbutaline sulfate injection, is a betaadrenergic agonist bronchodilator available as a sterile, nonpyrogenic, aqueous solution in vials, for subcutaneous administration. See full prescribing information for perforomist inhalation solution. Zosyn piperacillin and tazobactam for injection, usp pharmacy bulk package not for direct infusion reconstituted stock solution must be transferred and further diluted for i. Highlights of prescribing information platinumresistant. See package insert for full prescribing information. In the pediatric study, a significantly greater p pdf april 10.
The package insert for eplerenone is more restrictive in its. Etopophos solutions may be administered at infusion rates up to 3. Highlights of prescribing information these highlights do not include all the information needed to use rapaflo safely and effectively. Treatment considerations with aldosterone receptor antagonists. While it is recognized that beta 2adrenergic receptors are the predominant receptors in bronchial smooth muscle, data indicates that there is a population of beta 2receptors in.
Bleeding risk see full prescribing information for complete boxed warning. Eplerenone is a new aldosterone receptor antagonist that will be used in the treatment of hypertension. Zerbaxa ceftolozane and tazobactam for injection, for intravenous use initial u. Highlights of prescribing information these highlights do not include all the information needed to use aromasin safely and effectively. Sacubitril and valsartan entresto drug monograph september 2015 updated version may be found at. Highlights of prescribing information concomitant use. Highlights of prescribing information these highlights do not include allthe information needed to use corlanorsafely and effectively. Aug 08, 2019 eplerenone package insert pdf inspra eplerenone product monograph. Product information for auspar inspra eplerenone pfizer australia pty ltd pm. Serum potassium monitoring should continue once eplerenone has been restarted again.
Inspra tablets, 25 mg, are yellow diamond biconvex filmcoated tablets. After reconstitution, it should be administered by intramuscular im or intravenous iv routes see dosage and administration. They are debossed with pfizer on one side and nsr over 25 on the other. Highlights of prescribing information in patients with.
Ndc number size 0025171001 bottle of 30 tablets 0025171002 bottle of 90 tablets 0025171003 hospital unit dose. Ndc, product descriptions, prescribing information, dosage form, size, product materials, therapeutic category, brand name, generic, compares to brand. Pfizer rxpathways connects eligible patients to a range of assistance programs to help them access their pfizer prescriptions. Inspra eplerenone pfizer medical information canada. Pentamidine isethionate is a white crystalline powder soluble in water and glycerin. Information for the user inspra 25 mg filmcoated tablets inspra 50 mg filmcoated tablets eplerenone read all of this leaflet carefully before you start taking this medicine because it contains important information for you.
Lovaza omega3acid ethyl esters capsules are supplied as 1gram transparent, softgelatin capsules filled with lightyellow oil and bearing the designation gs fh2. Like spironolactone, it is a compound that can be associated with the development of hyperkalemia. Table of contents description clinical pharmacology indications and usage contraindications precautions adverse reactions dosage and administration how supplied storage references smallpox vaccine dried, calf lymph type dryvax dried smallpox vaccine rx. Package insert eplerenone eplerenone inspra will be released in the near future. Highlights of prescribing information coadministration with. Highlights of prescribing information these highlights do not include all the information needed to use per foromist inhalation solution safely and effectively. Highlights of prescribing information these highlights do not include all the information needed to use effientsafely and effectively. Adrs that were unpredictable from the package insert of selara tablets were. The product label, or package insert, is the manual for the safe. Package insert dryvax smallpox vaccine, dried, calf lymph. Each gram of protopic ointment contains ww either 0. Therefore, the same prescription considerations that are applied to spironolactone should be directed to its use. Safety and antihypertensive effect of selara eplerenone.
Aliqopa copanlisib for injection, for intravenous use. Lowering blood pressure reduces the risk of fatal and nonfatal cardiovascular cv events, primarily strokes and mi. Highlights of prescribing information these highlights do. Follow applicable special handling and disposal procedures. Easy to read fda package insert, drug facts, dosage and administration, and adverse effects for inspra eplerenone. No consistent effects of inspra on heart rate, qrs duration, or pr or qt interval were observed in 147 normal subjects evaluated for electrocardiographic changes during pharmacokinetic studies. Antihypertensive effect of the mineralocorticoid receptor antagonist eplerenone. These benefits have been seen in controlled trials of antihypertensive drugs from a wide variety of pharmacologic classes. Eplerenone package insert pdf inspra eplerenone product monograph.
A total of 690 patients were treated for over 6 months and 106 patients were treated for over 1 year. Infusion to reduce the development of drugresistant bacteria and maintain the effectiveness of zosyn. Consult the full prescribing information prior to use for potential drug interactions. Inspra has been evaluated for safety in 3091 patients treated for hypertension. Inspra for oral administration contains 25 mg or 50 mg of eplerenone and the following inactive ingredients. The following comments will hopefully clarify some of the issues surrounding the use of this compound. Highlights of prescribing information concomitant use with. Highlights of prescribing information these highlights do not include all the information needed to use entereg safely and effectively. Highlights of prescribing information these highlights do not include all the information needed to use azasite safely and effectively. Patients with essential hypertension who were eplerenonenaive were recruited. Feb 15, 2004 compared with other commonly used antihypertensive medications, eplerenone is effective in lowering blood pressure when used alone or as addon therapy.
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